1936 年 23 巻 1 号 p. 53-62
The writer conducted histological studies of Lu-jung, the Chinese drug, comparing it with the growing antlers of Cervus mantchuricus Swinhoe, the best material of this drug in Manchuria. The sections were stained with hæmatoxyline and cosine. The results are as follows :
1. The histological structure of Lu-jung is the same as that of the growing antlers of Cervus mantchuricus, consisting of the skin and the osseous tissues. The skin covering the young antler does not differ greatly from ordinary skin. It has hair follicles and numerous sebaceous glands, but no sweat-glands. The corium contains bundles of connective-tissue, and is rather cellular. Under the corium, in the layer corresponding to the stratum subcutaneum of other parts of the body, fat cells are totally absent. Blood vessels are present in and under the corium, but the writer failed to observe any nerve bundles.
2. The underlying tissues of the cutaneous structure differ greatly according to the growing stages of the antler. In the apex of the antler, there are enormous numbers of closely packed mesenchym cells, and the presence of numerous spindle-shaped cells gives it the appearance of a spindle cell sarcoma. These spindle-shaped mesenchym cells enter into the formation of the preosseous tissues as the antler grows, therefore, the youngest cells of the developing antler exist in the apex, and the more differentiated cells appear in the lower part. These tissues are rich with young blood vessels which run parallel with the skin; the structure of these newly-formed vessels is very simple.
3. Near the base of the antler, the preosseous tissues begin to ossify, and the process of ossification keeps pace with the growth of the antler, so that in the area between the mesenchymal tissues of the apex and the ossified tissues in the lower part, there can be seen developmental differentiations of all stages of the antler. These differentiations of the cells in the same stratum of the antler are found to be more remarkable in the center than in the periphery.
4. The newly-formed small blood vessels in the apex become larger as they descend toward the base of the antler; and no indication of the function of the blood creation is seen in any part.
5. From the results of these histological studies it may be assumed that high grade Lu-jung is made of younger antlers than the low grade. The histological figures of the high grade Lu-jung (¥100—200 per 37, 5 g) show the preosseous stage, while the low grade (¥30—50 per 37, 5 g) show the osseous stage. [cf. Original (Japanese) p. 53.] (Author's Abstract.)