ナイトロジェンマスタード静注によつて起る白血球減少に關する實驗的研究

抄録

In rabbits, the intravenous injection of HN₂resulted in severe leucopenia and depression in serum cholinesterase activity, without change of electrophoretic pattern of serum. Administration of folic acid, cystein and methionine plus vitamin B₁₂before injecting HN₂, resulted in partial protection against the leucopenia induced by HN₂. But administration of methionine and vitamin B₁₂alone was less effective, even with large doses. The depression of the serum cholinesterase was related to the severity of leucopenia. One mechanism of HN2 action is inactivation of SH bearing enzymes but such mechanism is not the only possibility.