抄録
1. Weanling rats were orally administered 1.5mg/day/rat of vitamin K3 (×10 group), 15mg/day/rat of vitamin K3 (×100 group) and 150mg/day/rat of vitamin K3 (×1, 000 group). The experimental group was treated for 12 wk. Increase in body wt. of weanling rats was low in the 150mg/day/rat group, and an enlarged spleen in the males was also observed in the same group.
2. Mother rats were fed on the same diets as the 3 experimental groups for about 20 days before the pregnancy and then through the gestation and natal periods. The offspring were fed a normal diet during the 12wk. after being weaned. Increase in body wt. of weanling rats did not differ among the subjects, and abnormalities in organs were also absent.
3. Mother rats were fed on the same experimental method No. 2 through the gestation, neonatal and lactation periods. The offspring were fed on a normal diet for 12 wk. after being weaned. As for the increase in body wt. of weanling rats, there was no difference found in any group, and abnormalities of organs were absent.
4. Mother rats about 20 days before pregnancy and through the gastation period, and weanling rats for 12 wk. after being weaned were given 150mg/day/rat of vitamin K3. These subjects were normal as to the number of RBC and WBC, values of hematocrit and hemoglobin, bleeding time and prothrombin time, blood sugar, hemoglobin urea.
5. Mother and weanling rats fed on the same experimental method No. 4 revealed high values for Icterus Index and bilirubin. The experimental offspring of mother rats fed on a normal diet after neonatal and lactation periods had normal values for Icterus Index and bilirubin.
