Abstract
The present experiments were carried out to determine the effect of drugs on the production of stress ulcer and output of Pontamine Sky Blue 6BX (PSB) in gastric juice and gastric secretion. The following results were obtained. Drugs inhibiting ulceration (except phenoxybenzamine) decreased gastric secretion and increased the pH value of gastric juice in rats. It is therefore suggested that the reduction of gastric juice may play an important role in prevention of stress ulcer. Propranolol, DCI and chlorpromazine prevented the decrease in output of PSB, as observed under stress. These results indicate, that prevention of stress-induced decrease in blood flow to the stomach wall may contribute to the inhibition of stress ulcer.
