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Volume 70, Issue 1
Displaying 1-11 of 11 articles from this issue
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Sadao NAKANE, Takeshi SAKAI1974 Volume 70 Issue 1 Pages 1-7
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSThe present experiments were carried out to determine the effect of drugs on the production of stress ulcer and output of Pontamine Sky Blue 6BX (PSB) in gastric juice and gastric secretion. The following results were obtained. Drugs inhibiting ulceration (except phenoxybenzamine) decreased gastric secretion and increased the pH value of gastric juice in rats. It is therefore suggested that the reduction of gastric juice may play an important role in prevention of stress ulcer. Propranolol, DCI and chlorpromazine prevented the decrease in output of PSB, as observed under stress. These results indicate, that prevention of stress-induced decrease in blood flow to the stomach wall may contribute to the inhibition of stress ulcer.View full abstractDownload PDF (2872K) -
—Changes of brain polyamine in aggressive mice induced by electro-shock and isolation, and effects of LiCl on behavior in aggressive mice—.Takeshi TADANO, Masahiro ONOKI, Kensuke KISARA1974 Volume 70 Issue 1 Pages 9-18
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSAggressive patterns such as mounting, attacking and vocalization appeared in aggressive mice induced by electro-shock (ES-mice), however, only attacking behavior was marked in aggressive mice, isolated for 3 weeks (IS-mice). In ES-mice, spermine markedly increased as compared with that of aggregated and nonaggressive mice, while NA, DA, 5-HT and spermidine were unchanged. In IS-mice, attacking intensity gradually increased in proportion to the period of isolation and increase in concentration of spermidine paralled the increase in attacking. Each amine remained unchanged in mice which were not aggressive even though isolation was carried out for 3 or 4 weeks. When LiCl (50 mg/kg) was injected i.p. into IS-mice twice a day for ten days, aggressive patterns completely disappeared on the 10th day. This chronic treatment with LiCI (50 mg/kg), further increased the spermine in IS-mice.View full abstractDownload PDF (4601K) -
Shigenori WATANABE, Hiroyoshi NISHI, Showa UEKI1974 Volume 70 Issue 1 Pages 19-37
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSEEG effects of hydroxyzine were investigated in unanesthetized rabbits with chronic electrode implants. A comparison was then made with the effects of diazepam and chlorpromazine. Hydroxyzine, in doses of 2 ?? 5 mg/kg i.v., caused a drowsy pattern in spontaneous EEG, with behavioral sedation; i.e. high voltage slow waves and spindle bursts increased in EEG of the neocortex and amygdala, while the hippocampal theta rhythm was desynchronized. These effects of hydroxyzine were qualitatively similar even at doses of 10 ?? 15 mg/kg i.v., but the animals occasionally exerted behavioral arousal; i.e. a dissociation was observed between EEG and behavior. The EEG arousal responses to auditory as well as electric stimulation of the mesencephalic reticular formation, the posterior hypothalamus and the centro-median thalamic nucleus were markedly depressed by hydroxyzine and diazepam, while chlorpromazine showed little effect on the arousal response to mesencephalic reticular stimulation. The photic driving response elicited by flash light on the visual cortex was slightly depressed by hydroxyzine. The recruiting response was slightly enhanced by hydroxyzine and chlorpromazine, while it was depressed by diazepam. The hippocampal and amygdaloid afterdischarges were prolonged in duration by hydroxyzine at doses of 2 ?? 5 mg/kg i.v., but were rather depressed at doses of 10 ?? 15 mg/kg i.v. These after-discharges were potentiated by chlorpromazine at doses of 2 ?? 5 mg/kg i.v. and were depressed by diazepam at doses of 1 ?? 5 mg/kg i.v.. respectively.View full abstractDownload PDF (7283K) -
Tamotsu FUKUDA1974 Volume 70 Issue 1 Pages 39-46
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSMethods for estimating minimal lethal doses and for determining duration of action of ouabain, proscillaridin A, α-acetyldigoxin, β-acetyldigoxin, digoxin and digitoxin were investigated in the guinea-pig. The minimal lethal dose of these drugs was estimated by infusion-toxicity in which the optimal infusion time and speed for a maximal utilization of drugs resulted in a minimal value of lethal doses (the method of Kosswig and Engelhardt). Duration of action of these drugs was determined by the method of Rand, Stafford and Thorp. The relationship between the elimination of these drugs and the duration of action provides an estimate for the rates of elimination. The rate of elimination (% LD/min) was 16 for ouabain, 14 for proscillaridin A, 9 for β-acetyldigoxin, 6 for α-acetyldigoxin, 4 for digoxin and 1 for digitoxin.View full abstractDownload PDF (3769K) -
Akihide KODA, Masahiko HIRAMATSU, Yoichi YOSHIDA1974 Volume 70 Issue 1 Pages 47-63
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSAdult male rats were administered orally 0.2 to 5.0 mg/kg/day × 30 of extract of cattle prostate (PE), which is clinically useful for the therapy of prostatic hypertrophy. The prostates were examined histologically as well as biochemically. In the PE-treated rats, no appreciable change was found in the weight and histological picture of prostate. There was, however, a fairly good increase in the respiration of the prostate when glucose and/or pyruvate was used as a substrate. An increase in the activities of aconitase and isocitrate dehydrogenase involved in TCA-cycle was also observed. These findings suggest the possible utilization of PE as a remedy for prostatic hypertrophy.View full abstractDownload PDF (8140K) -
Akihide KODA, Masahiko HIRAMATSU, Yoichi YOSHIDA1974 Volume 70 Issue 1 Pages 65-70
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSA study was made of the effect of PE on respiration in prostate tissue of three species including rat, dog and human, in addition to that in the liver of the rat. In the prostate tissue of the rat, the respiration was distinctly higher than in the other species, and was increased by PE when citrate and/or succinate was used as a substrate. On the contrary, the degree of respiration in the liver of the rat was approx. one third compared to that in the prostate, and was slightly increased by PE, without a substrate or glucose. Respiration in the prostate tissue of the dog was dramatically increased when succinate was used as a substrate, but was hardly affected by glucose and citrate. PE increased the respiration in the presence of citrate and/or succinate as a substrate. Succinate increased dramatically, respiration in the prostate tissue from humans, the same of which was further re-inforced by PE with the same substrate.View full abstractDownload PDF (2590K) -
Shunkichi TAMURA, Shigeru NOZAKI1974 Volume 70 Issue 1 Pages 71-88
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSResults are as follows: 1) There were no changes in weight gain of rats with administration of 2, 500 mg/kg and 10, 000 mg/kg of GA-56, but gain in weight of rats on 40, 000 mg/kg for 30 days, decreased. 2) There were no changes in RBC, WBC, Hgb, Ht and hemogramm. 3) There was no prolongation of bleeding time and no delayed action in coagulation time. 4) There were no changes in liver function, blood sugar and serum protein content, and natrium ion and potassium ion in serum. 5) Urobilinogen, bilirubin and occult blood counts in urine of rats were all negative. 6) A difference in organ weight was observed in the 40, 000 mg/kg group, but not so in the 2, 500 mg/kg group and the 10, 000 mg/kg group as compared to the control. 7) There were no pathological changes in any organ of rats on a large dose of GA-56.View full abstractDownload PDF (9715K) -
Pharmacological studies of a liapse GA-56 produced by Pseudomonas sp. IV. Chronic toxicity of GA-56.Shunkichi TAMURA, Shigeru NOZAKI1974 Volume 70 Issue 1 Pages 89-105
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSResults are as follows : 1) There were no changes in body weight gain of rats with administration of 4, 000 mg/kg and 10, 000 mg/kg of GA-56, but gain in body weight of rats on 25, 000 mg/kg for 26 weeks, decreased. 2) There were no changes in RBC, WBC, Hgb, Ht and hemmogramm. 3) There was no prolongation of bleeding time and no delayed action in coagulation time. 4) There were no changes in liver function, blood sugar and serum protein content, and natrium ion and potassium ion in serum. 5) Urobilinogen, bilirubin and occult blood counts in urine of rats were all negative. 6) A difference in organ weight was observed in the 25, 000 mg/kg group, but not so in the 4, 000 mg/kg group and the 10, 000 mg/kg group as compared to the control. 7) There were no pathological changes in any organ of rats on a large dose of GA-56.View full abstractDownload PDF (9125K) -
Shunkichi TAMURA, Shoji TSUTSUMI, Shigeru NOZAKI1974 Volume 70 Issue 1 Pages 107-118
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSIn this paper is described an experimental study of GA-56 which was developed to improve lipid metabolism regarding teratogenic effect. The mother's condition (general appearance, body weight), pregnancy status by Cesarean section (dead fetuses, body weight, sex ratio, gross and skeletal malformation) and fetal appearance after a natural delivery (pregnant periods, number, growth and nursing ratio) were all examined. In both mice and rats administered 8, 000 mg/kg of GA-56, there was an inhibition of increasing body weight and a slight increase in dead fetuses. In the groups on 500 mg/kg and 2, 000 mg/kg no effect on the mother's condition, pregnancy status and delivered fetal appearance was observed.View full abstractDownload PDF (5584K) -
Jyo MORI, Yoshihiko SATO, Takeo OHASHI, Masahiro HITOMI1974 Volume 70 Issue 1 Pages 119-126
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSThe pharmacological effects of amantadine were studied and compared with those of trihexyphenidyl, promethazine and imipramine. Amantadine was not inhibitory to the tremor induced by tremorine and oxotremorine in mice, but was inhibitory to the catatonia induced by neuroleptics in rats. Amantadine potentiated the effect of L-dopa in motor activity and the effect of methamphetamine in Sidman type conditioned avoidance response. In these effects, amantadine was essentially as active as other anti-parkinson drugs and imipramine. The effect of amantadine was one-tenth that of other antiparkinson drugs in inhibiting dopamine uptake into the striatal synaptosomes of rat. However, amantadine was more effective regarding dopamine uptake into the aminergic neuron terminals in the iris and median eminence of reserpinized rats.View full abstractDownload PDF (3855K) -
Atsushige SATO, Kazuko OZAWA, Tohru SASAKI1974 Volume 70 Issue 1 Pages 127-133
Published: 1974
Released on J-STAGE: March 29, 2007
JOURNAL FREE ACCESSThe effects of cadmium and zinc were studied on two diploid cell strains ; RP, of rabbit incisor tooth germ origin and RC, of rat calvaria origin, and one heteroploid cell strain ; L, of mouse subcutaneous tissue origin. Results are as follows : 1) The concentrations of 0.69 ?? 22.0 μM CdCl2 caused inhibition of the growth of three cell strains. The LD50 of CdCl2 for RP, RC and L was found to be 11.44, 2.29 and 2.20μM respectively. A strain specificity to the injurious effects of cadmium was apparent. 2) The cadmium contents of two cell strains exposed to 5.5 μM CdCl2 for different periods of time were measured. At 24 hr the cadmium contents in RP and RC cells were 1.108 ± 0.063 and 0.881 ± 0.092 μg per 106 cells respectively. The RC cell, which was more susceptable to cadmium, ranked lower in the content of this element. 3) Zinc prevented the inhibitory effect of cadmium on the growth of three cell strains. 4) Measurement of the zinc content of cells in relation to the differential susceptibility to cadmium in cell strains was performed. The zinc contents in RP and RC cells were 2.01 ± 0.93 and 0.99 ± 0.07 μg per 106 cells. The RP cell, which ranked higher in the zinc content was lower in susceptibility to cadmium.View full abstractDownload PDF (3424K)
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