Abstract
Adult male rats were administered orally 0.2 to 5.0 mg/kg/day × 30 of extract of cattle prostate (PE), which is clinically useful for the therapy of prostatic hypertrophy. The prostates were examined histologically as well as biochemically. In the PE-treated rats, no appreciable change was found in the weight and histological picture of prostate. There was, however, a fairly good increase in the respiration of the prostate when glucose and/or pyruvate was used as a substrate. An increase in the activities of aconitase and isocitrate dehydrogenase involved in TCA-cycle was also observed. These findings suggest the possible utilization of PE as a remedy for prostatic hypertrophy.
