Abstract
Results are as follows: 1) There were no changes in weight gain of rats with administration of 2, 500 mg/kg and 10, 000 mg/kg of GA-56, but gain in weight of rats on 40, 000 mg/kg for 30 days, decreased. 2) There were no changes in RBC, WBC, Hgb, Ht and hemogramm. 3) There was no prolongation of bleeding time and no delayed action in coagulation time. 4) There were no changes in liver function, blood sugar and serum protein content, and natrium ion and potassium ion in serum. 5) Urobilinogen, bilirubin and occult blood counts in urine of rats were all negative. 6) A difference in organ weight was observed in the 40, 000 mg/kg group, but not so in the 2, 500 mg/kg group and the 10, 000 mg/kg group as compared to the control. 7) There were no pathological changes in any organ of rats on a large dose of GA-56.
