Suppression of Hydrogen Peroxide-Induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Chemically Modified Curcumin

Tsutomu NAKAYAMA; Itsuko HARAGUCHI; Kei HASHIMOTO; Yasunori SUGIYAMA; Toshihiko OSAWA

doi:10.3136/fsti9596t9798.3.74

Notes

Suppression of Hydrogen Peroxide-Induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Chemically Modified Curcumin

Tsutomu NAKAYAMA, Itsuko HARAGUCHI, Kei HASHIMOTO, Yasunori SUGIYAMA, Toshihiko OSAWA

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Keywords: curcumin, turmeric, hydrogen peroxide, V79, cytotoxicity, polyphenol, cultured cell

JOURNAL OPEN ACCESS

1997 Volume 3 Issue 1 Pages 74-76

DOI https://doi.org/10.3136/fsti9596t9798.3.74

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Abstract

We assessed the inhibitory effects of curcumin and its chemically modified homologues against H₂O₂-induced cytotoxicity toward Chinese hamster lung fibroblasts V79 cells with a colony formation assay. Among 4 curcuminoids, dihydroxycurcumin and dihydroxytetrahydrocurcumin suppressed H₂O₂-induced cytotoxicity. On the contrary, neither curcumin nor tetrahydrocurcumin showed any suppressive effects. These results support our empirical rule that the o-dihydroxy (catechol) moiety is essential for the inhibitory effects.

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