Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Min-Seok Kim
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
Gi-Wook Hwang
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
Shusuke Kuge
Department of Microbiology, Tohoku Pharmaceutical University
Akira Naganuma
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
Published: December 21, 2015Received: December 10, 2015Available on J-STAGE: December 21, 2015Accepted: December 16, 2015
Advance online publication: -
Revised: -
Arsenic is a hazardous element that exists widely in the environment. To elucidate the molecular mechanism involved in the onset of arsenic toxicity, we comprehensively searched for genes affecting the sensitivity of HEK293 cells to arsenite by using a siRNA library targeting approximately 17,000 human genes. As a result, we identified ACOT9, one of the acyl-coenzyme A thioesterases, as the gene conferring arsenite resistance to cells by knockdown.
