Fundamental Toxicological Sciences
Online ISSN : 2189-115X
Toxicomics Report
Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells
Masayuki SatoJin-Yong LeeMin-Seok KimTsutomu TakahashiAkira NaganumaGi-Wook Hwang
著者情報
キーワード: Methylmercury, Toxicity, Putrescine
ジャーナル フリー

2018 年 5 巻 2 号 p. 71-73

詳細
抄録

We previously reported fluctuating levels of many metabolites in the brain of mice administered methylmercury. In this study, addition of putrescine, a polyamine, to the medium was found to confer methylmercury resistance to C17.2 mouse neural stem cells with regard to metabolites increased by methylmercury in the mouse brain. However, putrescine had little effect on the cytotoxicity of heavy metals such as cadmium and inorganic mercury. These results suggest that putrescine may selectively alleviate methylmercury toxicity.

著者関連情報
© 2018 The Japanese Society of Toxicology
次の記事
feedback
Top