動脈硬化と胃底腺萎縮に関する研究

抄録

This study was carried out with the aim of clarifying the relation between arteriosclerosis and atrophy of the f undic glands. Histopathological, clinical and endoscopic studies were performed on 70 cases who were operated on in our hospital during the past ten years. Based on various clinical tests, we graded the severity of general arteriosclerosis according to a definite standa-rd, and determined the degree of atrophy of f undic glands and arteriosclerosis of the gastric wall from the histolog-ical findings.The results were as follows.1) There was no significant relation between general arteriosclerosis and atrophy of the f undic glands.2) The degree of arteriosclerosis of the gastric wall was closely related to the degree of f undic gland atrophy. This correlation suggests that gastric wall arteriosclerosis might promote f undic gland atrophy.3) No remarkable relationship could be found between general arteriosclerosis and gastric wall arteriosclerosis.4) The preoperative endoscopic findings of atrophic pa-ttern were compared with the histological findings of glandular atrophy in the resected stomachs. The visuali-zation of the submucosal vessels coincided well with the histological glandular atrophy in the fundic area. The frequency of the endoscopic appearance of submucosal vessels is higher in the cases of gastric wall arterioscler-osis than in the non-sclerotic group. From these results, we consider that the arteriosclerosis of the gastric wall elicits a deficiency of blood supply to the gastric wall causing a thinning of the mucus membr-ane and eventual glandular atrophy. As this phenomenon progresses the transparency of the mucosa increases and the vessels beneath the mucosa can be visualized.