抄録
A case of Bowen's disease with malignant lymphoma was presented. The relationship between Bowen's disease and other malignant tumors, with the exception of skin cancer, was discussed. Reviewing the recent 232 cases of Bowen's disease, the sex ratio, male to female, was found to be 1.6 :1. The average age of male and female was 64.3 years and 62. 7, respectively. In Japan, 319 cases of Bowen's disease have been reported to date. Among these, 31 cases (9.1%) of Bowen's disease developed malignant neoplasmas. This figure, 9.1 %, showed twice as much indence as that of earlier reports in Japan, and nearly equal to that of Andersen's. However, this figure was lower than that of American reports. The difference was statistically significant at the 1 % level, evaluating on the bases of Chi-square distribution. As for the complicated group of Bowen's disease with other malignant tumors, the ratio of Bowen's disease on unexposed area to that on exposed area was found to be 5.4:1, whereas for all Bowen's disease, it was 3.8:1. However, no significant difference was found between the former and the latter. The average age of former complicated group and of the latter was 63 years and 64 years, respectively. No significant difference was found between them. On the other hand, the sex ratio was statistically significant, namely, it was suspected that female patients of Bowen's disease were more susceptible to other malignant tumors than male. Comparing the incidence of malignant tumors in autopsy materials with that of malignant tumors complicated with Bowen's disease, it is suspected that carcinoma of uterus is highly associated with Bowen's disease. However, a hasty conclusion that there is a certain correlation between them must not be made, since five out of thirteen cases of uterus carcinoma went ahead of the Bowen's disease. The incidence of complication of each malignant tumor with other malignant tumors, in autopsy cases, was also showed. This incidence was compared with that of complicated Bowen's disease. Among the cases of carcinoma of uterus and rectum, no significant difference was found between them. If there is no correlation between carcinomaa of uterus and other malignant tumors, it can be concluded that Bowen's disease is not correlated with other malignant tumors.
