抄録
Endoscopic methylene blue staining method was done in 34 cases with the gastric cancer and 22 cases with other lesions. A gelatine capsule, which contains 100 mg of the methylene blue, was orally administered with protease (Pronase 20, 000 u), sodium bicarbonate (1g) and Gascon. After a couple of hours, endoscopic examination was done. Eighteen out of thirty four cases with the gastric cancer were markedly stained by methylene blue, while 6 cases were well stained and 6 cases were equivocal. But, 4 in all cases with cancer were not stained. Histologically, both well and poorly differentiated adenocarcinoma were well stained than signet-ring cell carcinoma. The staining form was not related to the size and location of the cancer, tonicity of the stomach, gastric juice secretion and gastric empting time. Methylene blue, which stained the cancer, is not incorporated into the mucous membrane, but just coats the mucus on the superficial membrane. It might be considered that the mucus secreted from the gastric cancer can easily bounds to the methylene blue in comparison with the conditions except the gastric cancer. About 25 % of the methylene blne is excreted into the urine within a few days. The side effect of the methylene blue was never observed, except one case who showed the slight increase of GPT and GOT.
