A case of esophagial ulcers associated with doxycycline therapy was reported. 50-year-old woman came to us because of the onset of retrosternal burning pain. She had taken two capsules of doxycycline hydrochlorate (200 mg) the previous night just before going to sleep. She had no history of dysphagia, heart disease or esophagial stenosis. The roentgenogram of the esophagus revealed slightly irregular wall of midesophagus in 1 cm length (Fig. 1). Esophagoscopy revealed three small esophagial ulcers, 5 mm in diameter, laying in the transvers axis of esophagus, located 24 cm from the incisors (Fig. 2). Biopsy specimens of the ulcers were reported as benign esophagial ulcer with round cell infiltration (Fig. 3, 4). Roentgenography and Esophagoscopy, three weeks later, showed the ulcers to be completely healed (Fig. 5, 6). The etiology of esophagial ulcer associated with drug therapy and special diet of Japanese was discussed.
