Abstract
42-year-old female patient, who had been diagnosed to have giant rugae gastritis since the age of 35, was admitted to our hospital because of iron deficiency anemia (hemoglobin content of 1.9 g/dl, serum iron level 16, ug/dl) and hypoproteinemia (total protein 3.6 g/dl). Huge gastric folds were observed on radiography and endoscopy. Endoscopic ultrasonography demonstrated the huge folds conprizing the thickened second and third layers of the gasrric wall, accompanied by small cystic components. Protein loss from the stomach was confirmed by scintigram using 99mTc-DTPA-HSA. The histology obtained by endoscopic resection of the gastric folds revealed massive hyperplasia of the f oveolar epithelium with cystic dilation of the glands, consistent with Menetrier's disease. After oral administration of f amotidine 40mg daily, the levels of homoglobin and serum protein became normal, although there was no significant change on the giant folds.
