Determination of Aortic Medial Wall Smooth Muscle Cell and Nucleic DNA in Stroke-Prone Hypertensive Rats

Abstract

1) On a total 147 cases i.e. 45 of WKY and 99 of stroke-prone spontaneously hypertensive rats (SHRSP), histological considerations and subsequent comparative quantitative studies by microspectrophotometry were made of the amount of the thoratic aortic smooth muscle cell and the progress with age of its nucleic DNA synthesizing power.
2) From after birth to 300-day-level, WKY smooth muscle cell increases with arterial growth from 29.9 to 53.8% E and then from 400-daylevel decrease gradually to 48.4%E.
3) SHRSP smooth muscle rapidly increase from 35.0%E at less thatn 100 days after birth to 74.3%E on 200-day-level and further increase (77.8%E) on 400-dat-level and then decrease gradually.
4) WKY nucleic DAN increase from 96.5AU at less than 100 days after birth to 167.9AU on 200-day-level and then decrease.
5) SHRSP nucleic DNA increase (261.7AU) already at less than 100 days after birth, increase gradually up to 300-day-level (178.7AU) and then decrease.
6) SHRSP smooth muscle cell is abnormal in kinetics and nucleic synthesizing power with WKY, which together with dysmetabolism of elastin, collagen, acid mucopolysaccahride and reported already, results obviously from the pathology of hypertension.