Determination of Aortic Medial Tissue Acid Mucopolysaccharide and Glycoprotein in Stroke-Prone Spontaneously Hypertensive Rats

Abstract

1. According to the microspectrophotmetric procedure changes by age of acid mucopolysaccharide and glycoprotein in media of thoratic aortae were studied in a quantitative comparison using -Wistar Kyoto Rats (WKY) and- Stroke-Prone spontaneously Hypertensive Rats (SHRSP), -rats in total.
2. In WKY rats, acid mucopolysaccharide arrived at the maximal dose in the days of 300s and reduced gradually, while glycoprotein arrived at the maximal dose in the days of 100s and then indicated gradual by age.
3. In SHRSP rats, acid mucopolysaccharide far exceeded that of WKY rats in amount within 100 days, and rapidly reduced by the days of 200s. On the other hand glycoprotein showed a different characteristic from that it exceed a little that of WKY rats in amount by the days off 100s, but after that rapidly increased toward the days of 300s and maintained such high value even after the days of 400s.
4. Four constituents in arterial connective tissue completely destructd in SHRSP rats acompanied with abnormal hypertension. As a result lowered arterial functions abnormal vasometabolism were suggested sufficiently.