Osteocalcin Level in the Plasma of Normal Subjects and Patients with Metabolic Bone Disease

Correlation between Various Serum Parameters

Abstract

Serum concentration of γ-carboxyglutamic acid containing protein (BGP) was measured by the radioimmunoassay using anti-serum to bovine BGP which crossreacts with human BGP in normal subjects (108 male and 49 female), aged 30-80 years and 39 cases with thyroid diseases, 6 cases with chronic renal failure and 21 cases of postmenopausal osteoporosis. There was no age and sex difference in the serum level of BGP in the normal subjects. Serum level of BGP was significantly higher in hyperthyroidism and in chronic renal failure and it was significantly lower in postmenopausal osteoporosis than in the normal subjects. It was concluded that serum level of BSP was high in subjects with high bone turnover.