抄録
Since the process of amino acid substitution is stochastic, it is of great importance to consider the variance and covariance of the number of amino acid substitutions. Formulae for the variance and covariance of the number of amino acid substitutions estimated by Kimura's method are presented. The bootstrap method shows that the formulae are accurate. The formulae are useful for studies of molecular evolution, e.g., reconstruction of a minimum-evolution tree and the relative-rate test.
