Genetic Studies on the Kanamycin Resistance in Micrococcus Pyogenes var. Aureus (209 P)

抄録

Mutations to kanamycin resistance in Micrococcus pyogenes var. aureus. strain 209P, occur by way of an obligatory multi-step pattern, unlike the patterns of kanamycin resistance in mycobacteria, which are facultative single-step (facultative multi-step) patterns.
Kanamycin resistance is closely related with slow growth.
Mutations to kanamycin resistance were accompanied with simultaneous mutations to slow growth, and mutations to fast growth in slow-growing kanamycin-resistant mutants were accompanied with simultaneous mutations to kanamycin sensitiveness. It was suggested thus that both slow growth and kanamycin resistance belong to the same locus.