Proposal of new treatment algorithm for gastric cancer liver metastases: Up-front surgery or conversion surgery?

Nobuyuki Takemura; Akio Saiura; Hiromichi Ito; Kyoji Ito; Fuyuki Inagaki; Fuminori Mihara; Shusuke Yagi; Naoki Enomoto; Kyoko Nohara; Yosuke Inoue; Yu Takahashi; Kazuhiko Yamada; Norihiro Kokudo

doi:10.35772/ghm.2021.01102

This article has now been updated. Please use the final version.

Proposal of new treatment algorithm for gastric cancer liver metastases: Up-front surgery or conversion surgery?

Nobuyuki Takemura, Akio Saiura, Hiromichi Ito, Kyoji Ito, Fuyuki Inagaki, Fuminori Mihara, Shusuke Yagi, Naoki Enomoto, Kyoko Nohara, Yosuke Inoue, Yu Takahashi, Kazuhiko Yamada, Norihiro Kokudo

Author information

Nobuyuki Takemura
Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Akio Saiura
Department of Hepatobiliary Pancreatic Surgery, Juntendo University Hospital, Tokyo, Japan.
Hiromichi Ito
Department of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital, Tokyo, Japan.
Kyoji Ito
Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Fuyuki Inagaki
Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Fuminori Mihara
Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Shusuke Yagi
Department of Surgery, Upper Abdominal Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Naoki Enomoto
Department of Surgery, Upper Abdominal Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Kyoko Nohara
Department of Surgery, Upper Abdominal Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Yosuke Inoue
Department of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital, Tokyo, Japan.
Yu Takahashi
Department of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital, Tokyo, Japan.
Kazuhiko Yamada
Department of Surgery, Upper Abdominal Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.
Norihiro Kokudo
Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine, Tokyo, Japan.

Keywords: gastric cancer liver metastases, treatment algorithm, conversion surgery, up-front surgery

JOURNAL FREE ACCESS Advance online publication

Article ID: 2021.01102

DOI https://doi.org/10.35772/ghm.2021.01102

The final version of this article is now available: Vol. 4 (2022), No. 1 pp. 57-60

Details

Abstract

Hepatectomy for gastric cancer liver metastases (GCLM) has a 5-year survival rate of 9-42%; however, indications for hepatectomy remain unclear. Many researchers have reported prognostic factors for GCLM after hepatectomy, but surgical indications vary according to the literature. Furthermore, the indication for optimal candidates for neoadjuvant chemotherapy and intensive chemotherapy is also unclear. To understand the indications for surgery and chemotherapy intended for hepatectomy for GCLM, a new treatment algorithm was created based on previously reported evidence from the viewpoint of hepatic surgeons.

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