Prevention of melanin accumulation by flavonoid glycosides
2023 年 11 巻 1 号 p. 1-9
詳細
2023 年 11 巻 1 号 p. 1-9
Many plant flavonoids are glycosylated and commonly reported benefits of flavonoid glycosides are anti-oxidants and anti-inflammatory activities which find application in disease prevention and management. Flavonoids have a very broad pharmacological spectrum, but their mechanisms of action are only partially understood. We have revealed that plant polyphenols and steroidal saponins activate autophagy and acid β-glucosidase (GBA), a lysosomal enzyme that plays an important role in autophagy. Epidermal GBA converts glucosylceramide to ceramide, which is important for generating optimal barrier function in the stratum corneum, the outermost layer of skin. In addition, keratinocytes regulate melanosome degradation through autophagy. Thus, compounds that increase the activity of GBA may promote the efficiency of autophagy in melanin metabolism. Several studies have demonstrated the anti-inflammatory activity of flavonoid glycosides but data on the usefulness of flavonoid glycosides for human skin are limited. Here, we investigated the melaninolytic activity of flavonoid glycosides in keratinocytes from human iPS cell. The hesperidin and naringin reduced melanin levels, and hesperidin activated autolysosome formation and GBA. Thus, we propose hesperidin as a potential melanin degrading agent with good safety profile.
