抄録
The pharmacological studies of CG-120 (Uralyt-U) were investigated in rats and rabbits.
CG-120 indicated a marked alkalogenic effects against normal rats, but its effects were weak in rabbits. CG-120 also showed protective and curative effects on acidotic rats induced by 0.5% anmmonium chloride.
On serum electrolytes in rats CG-120 were no influence, but sodium bicarbonate were the breakdown of electrolyte balance on rat serum.
In addition, CG-120 stimulated urinary excretion of uric acid with increasing of urinary volume in rats treated by 3% oxonic acid and 1% uric acid.
These observations suggested that CG-120 may be useful agents for the therapy of hyperuricemias (gout, urinary caluclus, etc.) as basic alkalogenic-drug.
