抄録
Materials: Two cases of gout in association with rheumatoid arthritis were made a investigation into purine metabolic system to obtain its etiological hints, because such these cases were very rare in frequency and it's clinical cause were still not know. The former case, a male aged 72 years, had previously in episode of gouty attack in addition with polyarthralgia. Diagnostic radiological pictures were observed punched out lesion and erosive changes in bones. The serum uric acid level was determined at the value of 10.3 mg/dl, besides rheumatoid factor was positive. Synovia procured from the wrist joint by open biopsy was histologically proved typical rheumatoid changes. The latter case, a male aged 47 years, had also an episode of gouty attack and polyarthralgia. Clinical features were demonstrated a lot of gouty nodules and some erosive changes were radiologically present in bones. Rheumatoid factor was positive at a titer of 1: 1024. Aspiration material from the nodule was revealed unequivocal MSU crystals under the microscopic observation.
Method: The contents of adenosien deaminase (ADA) activity in lymphocytes and erythrocytes were measured in each cases to study the enzymatic activity of purine metabolic system.
Results: The contents of ADA activity in erythrocytes were as high as those of simple gout. The contents of ADA in lymphocytes were higher than those of gout or rheumatoid arthritis respectively.
Conclusion: From the investigation, the etiology of these cases is speculated to be based on the anomalies of enzymatic activity in purine metabolic system.
