The influences of steroid hormone on the uric acid metabolism were evaluated by measuring serum and urine uric acid, uric acid clearance (Cua) and uric acid creatinine clearance ratio (Cua/ Ccr) in 10 control subjects and 14 patients being treated with prednisolone.
In patients being treated with prednisolone, serum uric acid was 3.8=E0.9mg/d1 (mean: LSD), urine uric acid was 3917E139mg/day, Cua was 7.49±2.67m1/min and Cua/Ccr was 12.7±4.8%.
In control subjects, serum uric acid was 5.5±0.9mg/d1, urine uric acid was 361±146mg/day, Cua was 4.30±1.95m1/min and Cua/ Ccr was 8.5±2.9%.
There were significant differences in serum uric acid (P0.01), Cua (P<0.05) and Cua/Ccr (P<0.05) between patients being treated with prednisolone and control subjects, but no significant differences in urine uric acid.
Serum uric acid significantly more decreased (P<0.05) and Cua and Cua/Ccr significantly more increased (P<0.01) in patients after treated than in before treated.
These results indicate that prednisolone may decrease the production of uric acid and may increase the renal clearance of uric acid.
