ラットにおける利尿薬の尿酸排泄抑制作用に関する研究
1983 年 7 巻 2 号 p. 111-119
詳細
1983 年 7 巻 2 号 p. 111-119
In order to evaluate the decrease of uric acid excretion as the cause of diuretic-induced hyperuricemia in experimental animals, clearance studies were performed using rats treated with furosemide and trichlormethiazide.
Acute administration of test diuretics at highly potent doses elevated the hematocrit, and decreased the inulin clearance, the urine-excreted amount of uric acid, the uric acid clearance and the fractional excretion of uric acid. The pyrazinoic acidsuppressible fractional excretion of uric acid was similar to those of both the control and diuretic-treated groups, which suggests accelerated uric acid reabsorption following diuretic administration.
Consecutive administration of trichlormethiazide in rats fed a low-sodium diet resulted in marked diuresis, body weight loss, hemoconcentration and hypokalemia. In these volume-depleted rats, inulin clearance, the urine-excreted amount of uric acid, uric acid clearance and the fractional excretion of uric acid clearly decreased. This indicates the importance of fluid volume contraction on both the decrease in the filtration rate and the change in the transtubular uric acid transport.
From the present findings, we concluded that the characteristics of the diuretics acting on uric acid retention could be understood in the experiments using rats.
