The purpose of this study was to investigate the effects of high purine intake on serum uric acid level. College students ingested a high purine diet containing 107 mg/day of purine nitrogen for twenty-eight days (N= 8), 174mg/day for seven days (N= 2), and 189mg /day for twenty-eight days (N= 7). In addition, we investigated the effects of high fat intake on serum uric acid level. Subjects ingested a high fat diet containing 50g/day of butter and 72 mg/day of purine nitrogen for thirty days (N= 14). During high purine intake, serum uric acid level increased after the 4th day, reaching a peak on Day 7 , and remained at this level. However after the intake period, serum uric acid level decreased and returned to pre - intake level on Day 7. Serum uric acid level during and after high fat intake showed a similar tendency. The increase ratio in serum uric acid level was 8.0-15.5% during high purine intake, but was 20% during high fat intake. During high purine intake, serum uric acid level reached a peak on Day 7, and remained at the level because uric acid clearance increased in parallel with serum uric acid level (+0.50∼+4.25 ml/min) , and therefore the balance between production and excretion of uric acid was maintained.
