抄録
Purpose: This study aimed to visualize glycative stress as part of a workplace health promotion program and evaluate the effects of a combined approach involving basic glycation education and easily implementable dietary improvements on skin autofluorescence (SAF) − an indicator of fluorescent advanced glycation end products (AGEs) − and other glycative stress– related indicators.
Methods: An open-label, non-randomized, parallel-group controlled study was conducted in 100 healthy adults who participated in an internal health promotion event. In the intervention group (n = 50), participants received feedback on skin AGE measurements, basic education on glycation, and an 8-week dietary improvement intervention based on the aminoguanidine (AG) equivalent, an index representing the inhibitory activity of foods against AGE production. In the control group (n = 50), only measurements and information provision were conducted, and no specific dietary intervention was implemented. The primary endpoint was skin autofluorescence (SAF), and the secondary endpoint was the glycative stress score assessed using AAD Lifeworks.
Results: SAF levels showed a significant decline in both groups (p ‹ 0.001): from 2.15 ± 0.47 to 1.95 ± 0.36 in the intervention group and from 2.21 ± 0.29 to 2.06 ± 0.35 in the control group. Although the overall between-group difference in change was not significant, subgroup analyses showed that the reduction was significantly more pronounced in the intervention group for women (p = 0.011) and those aged ≥ 40 years. Conversely, no such effect was found in night-shift workers.
Conclusion: This study was not a clinical trial designed to verify the effects of a specific food, but rather a social implementation study suggesting that workplace health measures combining visualization of glycation, evaluation of AGE-production inhibitory activity in foods using AG equivalents, and feasible dietary improvement may contribute to improvements in glycative stress – related indicators. The improvement in health indicators observed among all participants through this program can be a major benefit.
