抄録
The disorder of intracerebral accumulated amyloid beta (Aβ) drainage, as well as the drainage of various waste products related to brain metabolism and permanent biochemical reactions, lead to brain homeostasis disorder, the breakdown of important regulatory functions and to the occurrence of cerebral amyloid angiopathy and rapid development of genetically programmed Alzheimer's disease (AD). The brain does not have its own standard lymphatic networks and therefore this important role is mostly taken over by the perivascular system which is located in the areas within the basement membranes of capillaries, arterioles and arteries. The driving force of this drainage is not formed by previously stated forces that are conditioned by heart functioning through the accompanying arterial pulsations, but by the newly discovered internal force of arterial and arteriolar walls, the so-called vasomotion. Moving in the direction opposite from the direction of the blood stream and pulse wave, these pulsating forces are based on rhythmic intracellular oscillations of Ca2+ ion concentration in vascular smooth muscle cells. With the participation of a number of molecular components, these oscillations cause the vasomotion phenomenon and their disturbance leads to perivascular drainage alterations and severe complications. This paper gives us a thorough analysis of crucial events that lead to the perivascular system alterations.
