The drainage mechanism of beta amyloid (Aβ) from the intra-arterial perivascular space by LRP1 receptors of the blood brain barrier endothelial cells

抄録

A number of recent research studies related to the significantly important intra-arterial perivascular drainage pathway indicates its crucial role in maintaining the optimal brain homeostasis. Driven by the pulsatile vasomotion forces, this drainage carries and cleans a whole complex of brain metabolism waste products, especially beta amyloid (Aβ). In the case of a markedly increased intracerebral concentration, especially of toxic Aβ, or alterated vasomotion, the drainage pathway undergoes a burdening in the flow, its collapse, and sedimentation of waste particles, among them Aβ aggregates in particular. In addition to the Aβ elimination through this drainage pathway that ends in the neck paracarotide lymph nodes, the drainage from this space also takes place by endothelial receptors and the transcytosis mechanism through the cytoplasm of endothel cells into the capillary blood. The aim of this study is to present a detailed explanation of these drainages, with the special analysis of LRP1 receptor and its functions in these events.