マイクロ波(MW)を利用したタンデム環化反応

抄録

We have developed a new convenient tandem reaction, that is Sonogashira reaction, dehydration reaction, and cyclization reaction by nucleophilic attack of imine nitrogen to alkyne carbon under microwave irradiation. This method would be more useful and more applicable than the standard conventional methods. Furthermore, since the concept presented here would be applicable to a wide range of substituted aromatic 2-bromoaldehydes, substituted alkynes, and substituted 1,2-diaminocompounds to afford more functionalized condensed ring heteroaromatic compounds. We also developed new convenient synthetic methods of 1,4-bezoxazepines and 1,4-bezothiazepines under microwave irradiation.