Abstract
In order to combine with bacteria characteristically and antagonize to p-aminobenzoic acid, sulfa drugs need the resembling electron configuration, amine radical in 4-position and sulfonyl radical in 1-position of benzene nucleus, and then the distance between them should be nearly equal to that of p-aminobenzoic acid.
The mechanism of Homosulfanilamide and p-aminornethyphenyl-methylsulfone differ from that of the other sulfa drugs.
The mechanism of 4, 4'-diaminodiphenylsulfone and promizole have been thought to be as same as the ordinale sulfa drupe. The sulfone drugs, Promin, Diason and Sulphetrone, which are practised actually, dissociate to 4, 4'-diaminodiphenylsulfone partly inside body after treatment and it acts effectively against bacteria. Therefore, it is a memorable remedy to use 4, 4'-diaminodiphenylsulfone, applied itself by Lowe.
Here, I introduced newly synthesized sulfones and ethertype compounds which had a growth inhibiting action against antiacidophilic bacteria,
