Repura
Online ISSN : 2185-1352
Print ISSN : 0024-1008
ISSN-L : 0024-1008
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Volume 20, Issue 1
Displaying 1-5 of 5 articles from this issue
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  • BIOCHEMICRL GENETICS OF HUMAN BEINGS
    Hideo Kikkawa
    1951 Volume 20 Issue 1 Pages 1-5
    Published: January 30, 1951
    Released on J-STAGE: June 30, 2008
    DOIhttps://doi.org/10.5025/hansen1930.20.1_1
    JOURNAL FREE ACCESS
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    A mass of evidence has been accumulated indicating that genes located in the chromosomes control various inherited traits. But how they do it is a more difficult problem. In this paper, some important examples like hempohilia, alcaptonuria, phenyl-pyruvic acid idiocy, porphyrinuria, blood types, cancer etc, have been explained, as well as those relating to human kinds as bacteria and viruses.
    These results indicate that the gene-complex of an individual is the most important factor. Lastly questions of the day, i. e., leprosy have been discussed from the view point of bicohemical genetics.
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  • PHARMACE UTICAL CHEMISTRY OF SULFONE DRUGS
    Tsutomu Momose
    1951 Volume 20 Issue 1 Pages 6-11
    Published: January 30, 1951
    Released on J-STAGE: June 30, 2008
    DOIhttps://doi.org/10.5025/hansen1930.20.1_6
    JOURNAL FREE ACCESS
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    In order to combine with bacteria characteristically and antagonize to p-aminobenzoic acid, sulfa drugs need the resembling electron configuration, amine radical in 4-position and sulfonyl radical in 1-position of benzene nucleus, and then the distance between them should be nearly equal to that of p-aminobenzoic acid.
    The mechanism of Homosulfanilamide and p-aminornethyphenyl-methylsulfone differ from that of the other sulfa drugs.
    The mechanism of 4, 4'-diaminodiphenylsulfone and promizole have been thought to be as same as the ordinale sulfa drupe. The sulfone drugs, Promin, Diason and Sulphetrone, which are practised actually, dissociate to 4, 4'-diaminodiphenylsulfone partly inside body after treatment and it acts effectively against bacteria. Therefore, it is a memorable remedy to use 4, 4'-diaminodiphenylsulfone, applied itself by Lowe.
    Here, I introduced newly synthesized sulfones and ethertype compounds which had a growth inhibiting action against antiacidophilic bacteria,
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  • THE HISTO-PATHOLOGICAL STUDIES ON THE PERIPHERAL NERVES IN THE VARIOUS CLINICAL PHASES OF LEPROSY
    Kazuo Saikawa
    1951 Volume 20 Issue 1 Pages 12-15
    Published: January 30, 1951
    Released on J-STAGE: June 30, 2008
    DOIhttps://doi.org/10.5025/hansen1930.20.1_12
    JOURNAL FREE ACCESS
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    The author will report three cases of acute relapse which occured in the course of neural leprosy. The results of the histopathological observation were as following:
    (1) The histopathological observation of erythema corresponded with that of tuberculo- ide leprosy.
    (2) The observation of peripheral nerves showed the sings of so-called macula tubercu- loide as in tuberculoide leprosy.
    (3) Its clinical symptoms were like those of the bulbar palsy.
    (4) In the course of the acute relapse, "Mitsuda' s Reaction" reaction positive more strongly.
    (5) As the cause of the acute relapse, it is thought that lepra bacilli which have been latent in the peripheral nerves are poured into the circulation of the blood on the same oppotunity and show these sings in the skin and nerves.
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  • EXPERIMENTL STUDIES ON CHEMOTHERRPY OF LEPROSY
    Seiki Yanai
    1951 Volume 20 Issue 1 Pages 16-19
    Published: January 30, 1951
    Released on J-STAGE: June 30, 2008
    DOIhttps://doi.org/10.5025/hansen1930.20.1_16
    JOURNAL FREE ACCESS
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    I. Effects of Reducing and Oxidazing Agants on Rat Leprosy.
    1. Sodium thiosulfate, a reducing agent, produces a favorable effect upon lepromas in an inoculated part. In the distribution of leprosy bacilli in the body, however, there is no great difference between animal as treated and the control.
    2. Pottasium permanganate, an oxidazing agent, make the leproma markedly worse, and rat leprosy bacilli are found in greater numbers in this case than in the control.
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  • EXPERIMENTRL STUDIES ON CHEMOTHERAPY OF LEPROSY
    Seiki Yanai
    1951 Volume 20 Issue 1 Pages 20-23
    Published: January 30, 1951
    Released on J-STAGE: June 30, 2008
    DOIhttps://doi.org/10.5025/hansen1930.20.1_20
    JOURNAL FREE ACCESS
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    II. Effects of Several Other Chemical Substances upon Rat Leprosy. 1. Scharlachrot, thiocol and seraniol make the symptomes of rat leprosy worse. 2. Sephalantin has a tendency to make rat leprosy slightly worse. 3. Citroneral acts some what favorbly upon rat leprosy.
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