Abstract
The present paper is a report on the preventive and therapeutic actions of the newer chemotherapeutics, Promacetin and Proethyl, and, especially, on their combined effects with Cepharanthin on the development of the experimental rat-leprosy.
The results were as follows :
(1) Promacetin and Proethyl apparently possessed the preventive and therapeutic properties against the rat-leprosy, and the improvement noted in the animals treated with Promacetin was certainly more striking and rapid than that observed in those treated with Proethyl.
(2) So far as the present combined dosage of Cepharanthin, it did not potentiate the action of Promacetin or Proethyl, and appeared rather to be antagonistic against that.
(3) Although the therapeutic effect of Cepharanthin on the rat-leprosy is much or less able to be expected, the further trials are required as to its dosage.
