Abstract
For the purpose of selecting a mouse strain adequate for immunological experiments, comparative observations were made of the effects of BCG vaccination on the onset of murine leprosy in various uniform strains of mice (C 57 BL, dd, CFW, CF 1, and C 3 H). Mice used were of approximately the same age, and lived under the same dietary and environmental conditions.
It was found that two strains, C 3 H and CF 1, were adequate for immunological experiments in that the leproma developed to a much larger size whereas ulcers develo-ped more slowly.
In strains in which the leproma generally remained small and the ulcer formed early, such as C 57 BL, the differences between the vaccinated and non-vaccinated mice were less marked although the lepromas were palpable in the earlier stage of infection. Therefore, these strains seemed inadequate for the study of immune responses.
