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Volume 27, Issue 1
Displaying 1-9 of 9 articles from this issue
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I. HISTOCHEMICAL STUDY OF PHOSPHATASES IN THE CELLS IN TISSUE CULTURESTamotsu IMAEDA1958 Volume 27 Issue 1 Pages 1-13
Published: January 20, 1958
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESS -
2. THE HISTOCHEMICAL STUDY OF PHOSPHATASES IN THE LEPROUS LESIONSTamotsu IMAEDA1958 Volume 27 Issue 1 Pages 14-25
Published: January 20, 1958
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESS1. Phosphatase activity is observed in lepromatous skin lesions, lepromatous nerve lesions, tuberculoid skin lesions, tuberculoid nerve lesions and murine lepromas, using α-glycerop-hosphate, DNA, RNA, ATP and ADP as substrates.
2. Both epithelioid tubercles in tubercloid lesions and lepromasin lepromatous lesions show the various phosphatases activities similary. Especially infiltrating round cells and heavily stained in the lesions for phosphatases. Infering from these results, the various significance of phosphatases activities in lepromatous and tuberculoid lesions is discussed.
3. In tuberculoid and lepromatous nerve lesions, phosphatases are distributed more heavily than in skin lesions and this suggests the phosphatases are related to the splitting of nerves.
4. Murine lepromas show the similar distribution of phosphatases as that of lepromatous skin lesions in human leprosy.View full abstractDownload PDF (862K) -
Shigenori ISHIHARA1958 Volume 27 Issue 1 Pages 26-36
Published: January 20, 1958
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThe occurrence of giant cells and the appearance of incluston bodies in the lesions of the skin was examined in 276 cases of leprosy.
1) In the tuberculoid type, giant cells were obsered in 22 of 28 cases (78.5 %) in the flourishing stage whereas in the absorption stage, they could not be found. Giant cells were noted in 22 of 180 cases (12%) of the lepromatous type.
2) Giant cells were observed in the skin lesions of the reactional stage in 19 of 45 cases of erythema nodosum leprosum, 3 of 4 cases of acute infiltration and 2 cases of acute exacerbation.
3) Giants cells which were observed included the typical Langhans type, the foreign body giant cell and the Touton type giant cell. It was noted that development was by clumping and division.
4) Examination of the relationship between appearance of giant cells and clinical sym-ptoms showed that the giant cells appeared in the flourishing stage of the tuberculoid and the declining stage of the lepromatous type.
5) Inclusion bodies were observed in the giant cells in 9 cases of the lepromatus type and 3 cases of erythema nodosum leprosum but were not observed in the tuberculoid type.
6) The inclusion bodies were asteroid in all 12 of the cases and Schaumann body could not be detected.View full abstractDownload PDF (1820K) -
STUDIES OF THE LEPROMIN REACTION (Part 5)Minoru FUKUDA1958 Volume 27 Issue 1 Pages 37-43
Published: January 20, 1958
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe Lepromin reaction was tested in leprosy patients using 1, 000, 5, 000, 10, 000, (original method), 30, 000, 50, 000, 70, 000, 100, 000, 300, 000 and 1, 000, 000 fold dilutions of Dharmendra's antigen.
1) Injection of concentrated antigen solutions (1: 1000, 1: 5000) in lepromatous cases which had given negative results to the original antigen showed a slight increase in the early reaction but a conversion to positive was rare whereas the late reaction frequently became positive especially in the case of the 1: 1, 000 antigen, with the diluted antigens, both the early and late reactions were weaker.
2) In the non-lepromatous cases, which had given positive results with the original antigen, dilution of the antigen resulted in a weakening of the early reaction. Similar results were noted in the late reaction.
3) Only the early reaction is of value in the classification of leprosy type using Dhar-mendra's antigen and up to 3-fold dilutions of the original antigen are quite accurate. It is suggested that up to 7-fold dilutions (1: 70, 000) may be used but in this case, a new criterion for evaluation should be devised.View full abstractDownload PDF (320K) -
Part 2. The Relation between Strains of Mice and Effects of BCG in Murine LeprosyYoichiro KAWAGUCHI1958 Volume 27 Issue 1 Pages 44-48
Published: January 20, 1958
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSFor the purpose of selecting a mouse strain adequate for immunological experiments, comparative observations were made of the effects of BCG vaccination on the onset of murine leprosy in various uniform strains of mice (C 57 BL, dd, CFW, CF 1, and C 3 H). Mice used were of approximately the same age, and lived under the same dietary and environmental conditions.
It was found that two strains, C 3 H and CF 1, were adequate for immunological experiments in that the leproma developed to a much larger size whereas ulcers develo-ped more slowly.
In strains in which the leproma generally remained small and the ulcer formed early, such as C 57 BL, the differences between the vaccinated and non-vaccinated mice were less marked although the lepromas were palpable in the earlier stage of infection. Therefore, these strains seemed inadequate for the study of immune responses.View full abstractDownload PDF (478K) -
Part 3. Strains of Mice for Experimental Chemotherapy of Murine LeprosyYoichiro KAWAGUCHI1958 Volume 27 Issue 1 Pages 49-53
Published: January 20, 1958
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe mice of different strains (C 57 BL, dd, CFW, CF 1, A, and C 3 H), which were inoculated subcutaneously with murine leprosy bacilli, were examined after the administion of Isonicotinic acid hydrazide and Pyrazinamide to select an adequate strain for the determinarion of efficacy of therapeutic agents.
The experiments were carried out in two series, namely,
1) inhibition of the onset and 2) therapy.
1) Inhibition of the onset
No significant difference was recognized among the mouse strains tested. A strain, such as C 57 BL, with a tendency toward earlier leproma formation, therefore, seemed adequate for leproma inhibition experiments.
2) Therapy
Slight difference was found between the treated and nontreated mice of the C 57 BL strain, whereas a remarkable one was found in the C 3 H strain. Therefore, the C 3 H strain was superior to the C 57 BL strain for thrapeutic experiments.View full abstractDownload PDF (269K) -
Kimishige SATO, Toshiaki KASUGA, Tadae ITO1958 Volume 27 Issue 1 Pages 54-61
Published: January 20, 1958
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSA case of leprosy in which pulmonary mycosis occurred was experienced. The patient was a 45 year old male with a history of leprosy of 20 years duration. He had received a total of 87 injections of Promin (13.05g) and the manifestations had become stabilized in the early part of 1956. In Sept. of the same year however, he had become afflicted with pleurisy of the right side. Streptomycin treatment was instituted after one month as there was a slight worsening in the symptoms whereupon he took a sudden turn for the worse with high fever and pain of the throat. The sputum was tuberculosis bacilli negative but a large number of mycotic spores and fibers were found. The general con-dition rapidly deteriorated and the patient died on November 9, 1956.
Autopsy findings verified the clinical diagnosis and changes due both to leprosy and mycosis were found.View full abstractDownload PDF (1306K) -
II. GEOGRAPHICAL DISTRIBUTION OF LEPROSY AND THE FAMILIAL RELATIONSHIPHiroichi KITANO1958 Volume 27 Issue 1 Pages 62-72
Published: January 20, 1958
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSA breakdown of the 292 reported cases of leprosy occurring in Gifu prefecture between 1936 and 1955 showed that a greater number were from the rural areas the cities. There were 11 towns and 27 villages however, in which not a single case was reported during this 20 year period. This is equal to 34% of of the total cities, towns and villages.
Of the total number of cases, 90% occurred in natives of the prefecture while the remaining 10% were Koreans.
The figures suggert that the percentage of leprosy cases in Korens is 13.0∼8.7 per 100, 000.
The prefecture was arbitrarily divided into 4 districts according to locale and economic status, It was found that there were districts in which the cases were on the decline, where it was yet prevalent, others where the number or cases appeared small due to poor medical facilities and still others where a large number of cases were a large number of cases were present in a single family.
The familial incidence was 23.3% (68 out of 292 cases) and the source of infection
was one of the parents in 38.2%, other siblngs 32.4% and the grandparente in 10.3%.View full abstractDownload PDF (1394K) -
[in Japanese]1958 Volume 27 Issue 1 Pages 73-78
Published: January 20, 1958
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSDownload PDF (539K)
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