STRAINS OF MICE FOR EXPERIMENTAL MURINE LEPROSY

Part 3. Strains of Mice for Experimental Chemotherapy of Murine Leprosy

Abstract

The mice of different strains (C 57 BL, dd, CFW, CF 1, A, and C 3 H), which were inoculated subcutaneously with murine leprosy bacilli, were examined after the administion of Isonicotinic acid hydrazide and Pyrazinamide to select an adequate strain for the determinarion of efficacy of therapeutic agents.
The experiments were carried out in two series, namely,
1) inhibition of the onset and 2) therapy.
1) Inhibition of the onset
No significant difference was recognized among the mouse strains tested. A strain, such as C 57 BL, with a tendency toward earlier leproma formation, therefore, seemed adequate for leproma inhibition experiments.
2) Therapy
Slight difference was found between the treated and nontreated mice of the C 57 BL strain, whereas a remarkable one was found in the C 3 H strain. Therefore, the C 3 H strain was superior to the C 57 BL strain for thrapeutic experiments.