Abstract
The chemotherapy of Promin resistant leprosy patients is now a serious problem in the leprosaria in Japan. In connection with the synthesis of new sulfone drugs usable for these patients this author was deeply interested in the fact that the compounds of hydrazine series do not antagonize PABA, and then synthesized a new sulfone compound, 4-amino-4'-hydrazinodiphenylsulf one (AHDS) as well as some other fundamental and representative compounds of 4'-substituted-4-aminodiphenylsulf ones. All of them were tested of their antibacterial and antifungal activities.
As the result of the experiment, it was found that both AHDS and 4'-hydroxy derivative possessstrong antibacterial activities, which were markedly influenced by the nature of the radicals at 4'position. This author is interested in both the antagonistic action of these two compounds againstbacteria, and their metabolism in the living body.
