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Volume 29 (1960)
- Issue 5-6 Pages 185-
- Issue 2 Pages 75-
- Issue 1 Pages 1-
Volume 29, Issue 2
Displaying 1-7 of 7 articles from this issue
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I. Antibacterial Activities of 4-Aminophenylsulfone Derivatives (With Special Reference to 4-Amino-4'-Hydrazinodiphenylsulfone)SADAE TSUTSUMI1960 Volume 29 Issue 2 Pages 75-79
Published: March 20, 1960
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe chemotherapy of Promin resistant leprosy patients is now a serious problem in the leprosaria in Japan. In connection with the synthesis of new sulfone drugs usable for these patients this author was deeply interested in the fact that the compounds of hydrazine series do not antagonize PABA, and then synthesized a new sulfone compound, 4-amino-4'-hydrazinodiphenylsulf one (AHDS) as well as some other fundamental and representative compounds of 4'-substituted-4-aminodiphenylsulf ones. All of them were tested of their antibacterial and antifungal activities.
As the result of the experiment, it was found that both AHDS and 4'-hydroxy derivative possessstrong antibacterial activities, which were markedly influenced by the nature of the radicals at 4'position. This author is interested in both the antagonistic action of these two compounds againstbacteria, and their metabolism in the living body.View full abstractDownload PDF (314K) -
II. Antibacterial Activities of 4-Aminophenylsulfone Derivatives (With Special Reference to 1-[p-Aminophenylsulfonyl]-2-[p-Alkoxyanilino]-Ethane)SADAE TSUTSUMI1960 Volume 29 Issue 2 Pages 80-87
Published: March 20, 1960
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSBeing interested in the fact that p-butoxyaniline shows a considerable antituberculous activity, this author synthesized some new sulfone compounds of p-alkoxyaniline in which their amino radical was substituted by 4-aminophenylsulfonylethylene radical. These compounds were also found having a specific antituberculous activity in vitro.
Their antibacterial and antifungal activities were compared, in connection with their chemical structure, with numerous other substances which belong to the similar groups or groups in connection.
The object of this author is to find out whether it is possible to expect the diverse mode of action of sulfones with the derivation of alkoxyether such as in the case of p-alkoxyaniline, which may be different in its mode of antimicrobial action, from the compound with 4-aminophenylsulfone radical, and also whether it is possible to find out some sulf one drugs with chemical skeleton entirely different from that of 4, 4'-diaminodiphenylsulfone, more neurotropic than DDS by the use of various amines instead of p-butoxyaniline.View full abstractDownload PDF (1654K) -
II. On Urinary Metabolites of Human Administered of 4, 4'-Diaminodiphenylsulfoxide (DDSD) with Special Reference to the In Vivo Metabolic Pattern of Sulfoxide Radical and the Isolation of its N-AcetylSADAE TSUTSUMI1960 Volume 29 Issue 2 Pages 88-95
Published: March 20, 1960
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSBeing interested in the electron theory to say that sulfoxide radicals (-SO-) possess stronger single bond character than sulfone radicals (-SO2) and the SO-radical of DDSO is the most labile one among diphenylsulfoxides15)-24), and at the same time in the bacteriological studies that some aliphatic sulfoxides such as Dimethylsulfoxide are reduced to those of sulfides by some strains of Enterobacte-riaceae11), 12), the author investigated the oxidation of DDSO to DDS or its reduction to 4, 4'-Diaminodi-phenylsulfide (DDSD) in the living body.
The results showed that the confirmation or presumption of usual N-conjugate such as mono-Acetyl-DDSO was possible, but neither oxidized nor reduced metabolite was detectable. (Labile N-conjugate of DDSO will be reported in the following paper.) Furthermore, no oxidized or reduced metabolite was detected from the urine of rabbits to which DDS or DDSD was administered. In the living body, accordingly, DDSO seems to exist as sulfoxide compounds.
So far as the fundamental diphenylsulfoxides are concerned, moreover, their antituberculous activity in vitro is inferior to that of sulfone series. Thus, it is not feasible to make the comparison of the specificity of DDSO and DDS at present.View full abstractDownload PDF (850K) -
III. On the Detecticn of Sulfon-Cilag in the Urine of Human and Rabbit Administered of HydroxyethylSADAE TSUTSUMI1960 Volume 29 Issue 2 Pages 96-99
Published: March 20, 1960
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSJackson et al. gave an inference on the oxidative metabolism of Hydroxyethyl to Sulfon-Cilag, and then Smith et al. reported on the isolation of the latter from the urine of cat administered ofHydroxyethyl.
However, details of analytical method and the findings of human being have not been reported asyet.
For the separation of these two drugs the author employed paper electrophoresis, and detected the.coloured belt of Sulfon-Cilag from the urine of human and rabbit administered of Hydroxyethyl.View full abstractDownload PDF (314K) -
AKIRA MAYAMA1960 Volume 29 Issue 2 Pages 100-103
Published: March 20, 1960
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSLow density lipoprotein fractions obtained from the sera of leprosy patients by preparative uitracentrifugation at 40, 000 r. p. m. (107, 000×g) and solvent 1.063g. per ml. for 8 hours. The effect of the fractions on phagocytosis of leucocytes from leprosy patients against tubercle bacilli was investigated.The phagocytic power of the leucocytes in the medium containing the serum lipoproteins was stronger than in the medium containing the serum itself. The antigenicity of the lipoprotein fractions, isolated from the sera of lepromatous or tuberculoid leprosy patients was also examined. Antisera for these fractions were produced in rabbits or chickens in usual manner. And then, the techniques of agar diffusion and agar immunoelectrophoresis were applied to the study. There was a marked difference in antigenicity between the fractions obtained from tuberculoid and those from lepromatous leprosy patients. The antibodies were not demonstrated in the antisera against lepromatous serum lipoprotein fractions. It was apparent that the fractions isolated from the sera of tuberculoid leprosy induced formation of antibodies against the sera and the serum lipoprotein of leprosy patients.View full abstractDownload PDF (278K) -
[in Japanese]1960 Volume 29 Issue 2 Pages 104-118
Published: March 20, 1960
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSDownload PDF (2564K) -
[in Japanese]1960 Volume 29 Issue 2 Pages 119-123
Published: March 20, 1960
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSDownload PDF (718K)
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