1960 Volume 29 Issue 2 Pages 80-87
Being interested in the fact that p-butoxyaniline shows a considerable antituberculous activity, this author synthesized some new sulfone compounds of p-alkoxyaniline in which their amino radical was substituted by 4-aminophenylsulfonylethylene radical. These compounds were also found having a specific antituberculous activity in vitro.
Their antibacterial and antifungal activities were compared, in connection with their chemical structure, with numerous other substances which belong to the similar groups or groups in connection.
The object of this author is to find out whether it is possible to expect the diverse mode of action of sulfones with the derivation of alkoxyether such as in the case of p-alkoxyaniline, which may be different in its mode of antimicrobial action, from the compound with 4-aminophenylsulfone radical, and also whether it is possible to find out some sulf one drugs with chemical skeleton entirely different from that of 4, 4'-diaminodiphenylsulfone, more neurotropic than DDS by the use of various amines instead of p-butoxyaniline.
