癩菌の結膜侵入に關する實驗的研究

櫻井 方策

doi:10.5025/hansen1930.7.5_707

癩菌の結膜侵入に關する實驗的研究

櫻井方策

著者情報

ジャーナルフリー

1936 年 7 巻 5 号 p. 707-721_6,47

DOI https://doi.org/10.5025/hansen1930.7.5_707

詳細

発行日: 1936/11/25 受付日: - J-STAGE公開日: 2008/12/10 受理日: - 早期公開日: - 改訂日: -
訂正情報
訂正日: 2008/12/10 訂正理由: - 訂正箇所: 著者情報訂正内容: 訂正前 : 櫻井方策¹⁾²⁾
訂正後 : 櫻井方策¹⁾

訂正日: 2008/12/10 訂正理由: - 訂正箇所: 所属機関情報訂正内容: 訂正前 :
1) 大阪帝國大學微生物病研究所
2) 癩治癩研究部

訂正後 :
1) 大阪帝國大學微生物病研究所癩治癩研究部

訂正日: 2008/12/10 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

訂正日: 2008/12/10 訂正理由: - 訂正箇所: 論文抄録訂正内容: Wrong : Leprosy is believed to be one of chronic contagious diseases, which is transmitted by contact. In the previous experiments the author painted an emulsion of a leprous nodule on the skin of the human body and rabbit. With a piece of the painted skin serial sections for microscopic examination were made. In these sections lepra bacilli were found penetrating the skin through a small crack or even an intact continuity. The penetration of the bacilli through the skin also was demonstrated in the skin of the mouse, in which the skin was rubbed after painting the emulsion, or with the rabbit, in which the hair was plucked off. These experimental results were reported in No. 2 of Vol. VI and VII of the journal Lepro.
In this experiment, 5 rabbits were employed and the emulsion was dropped into the conjunctival sac continuously for 30 minutes. In one of these rabbits the lachrymal duct was destroyed by cautery. Then the conjunctiva was excised for a microscopic examination.
In the nrst rabbit (No. 9) 3 bacilli could be found after examining 347 sections, in the second (No. 10) 11 bacilli in 155 sections, in the third (No. 11) 7 bacilli in 382 sectioi and in the forth with a closed lachrymal duct 5 bacilli in 103 sections. Among the penetrating bacilli 19 existed in the deep layer of the cutis, 7 in the middle layer, 4 close by the epithelial layer and 4 direct beneath the epithelium. One bacillus was found in the neibourhood of the Meibom's gland as well as in the wall and in the hollow of blood vessels respectively.
From these findings it was stated that lepra bacilli could enter into the deep layer of the cutis through the epithelial layer of the conjunctiva, and the bacilli in the cutis into the blood vessel penetrating the wall.
The question as to whether or not a leprous change could be caused by the bacilli, which entered into the cutis of the conjunctiva, was not solved. But summarizing the experimental works carried out by the present author, the skin could be regarded as a more favourable source than the conjunctiva, since the skin was far larger in extension and had far more occasions to contact with leprous carriers than the latter.
Right : Leprosy is believed to be one of chronic contagious diseases, which is transmitted by contact. In the previous experiments the author painted an emulsion of a leprous nodule on the skin of the human body and rabbit. With a piece of the painted skin serial sections for microscopic examination were made. In these sections lepra bacilli were found penetrating the skin through a small crack or even an intact continuity. The penetration of the bacilli through the skin also was demonstrated in the skin of the mouse, in which the skin was rubbed after painting the emulsion, or with the rabbit, in which the hair was plucked off. These experimental results were reported in No. 2 of Vol. VI and VII of the journal Lepro.
In this experiment, 5 rabbits were employed and the emulsion was dropped into the conjunctival sac continuously for 30 minutes. In one of these rabbits the lachrymal duct was destroyed by cautery. Then the conjunctiva was excised for a microscopic examination.
In the nrst rabbit (No. 9) 3 bacilli could be found after examining 347 sections, in the second (No. 10) 11 bacilli in 155 sections, in the third (No. 11) 7 bacilli in 382 sectioi and in the forth with a closed lachrymal duct 5 bacilli in 103 sections. Among the penetrating bacilli 19 existed in the deep layer of the cutis, 7 in the middle layer, 4 close by the epithelial layer and 4 direct beneath the epithelium. One bacillus was found in the neibourhood of the Meibom's gland as well as in the wall and in the hollow of blood vessels respectively.
From these findings it was stated that lepra bacilli could enter into the deep layer of the cutis through the epithelial layer of the conjunctiva, and the bacilli in the cutis into the blood vessel penetrating the wall.
The question as to whether or not a leprous change could be caused by the bacilli, which entered into the cutis of the conjunctiva, was not solved. But summarizing the experimental works carried out by the present author, the skin could be regarded as a more favourable source than the conjunctiva, since the skin was far larger in extension and had far more occasions to contact with leprous carriers than the latter.

訂正日: 2008/12/10 訂正理由: - 訂正箇所: 引用文献情報訂正内容: 訂正前 : 3) Dening:結核性限疾患の一般に就て(鹿兒島茂)實地醫家と臨床第59號1929
4) 大野内記:腺病の發生機轉に就て大阪醤學會雑誌第8巻第9號大正14年
5) 蘆名泰:眼結膜鼻腔咽腔よりの結核菌累積的感染の結果た就て(實驗的研究)結核第6巻第9號昭和3年
6) 加藤謙に一:結核菌皮膚侵入感染機轉に關する新實驗(第1報告)結核第5巻第7號昭和2年
8) 光田健輔:癩病の眼疾患に就て日本醫學第65號1910
12) 市川清:眼の癩腫に就て日本眼科學會雑誌第11巻1907
13) 増田隆:癩性點状角膜炎の病理解剖中央眼科醫報第12巻1920
14) 鮫島近二:癩性眼球の組織學的研究日本眼科學會雑誌第36巻1932
17) 瀬木本雄:前鞏膜のレプラ腫に就て日本眼科學雑誌第27巻1923
18) 行徳勝人:眼球癩の臨床的竝に病理組織學的知見補遣日本眼科學會雑誌 1926
19) 内田守:鼠癩の眼疾患に關する研究(第3報) レプラ第4巻第3號昭和8年
20) 籾木穂積:正常ラツテ眼の組織學的研究(第1報告)成醫會雑誌51巻7號昭和7年
22) 有住三郎:癩患者涙液中の抗酸性菌に就いてレプラ第4巻第3號昭和8年
23) 橋本喬:癩及び癩菌の研究に關する2,3の考察大阪醫事新誌7巻7號昭和11年
24) 櫻井方策癩菌の皮膚侵入に關する實驗的研究レプラ第6巻第2號昭和10年
25) 櫻井方策:癩菌の皮膚侵入に關する實驗的研究(第2報) レプラ第7巻第2號昭和11年.

訂正後 : 3) Dening:結核性限疾患の一般に就て(鹿兒島茂)實地醫家と臨床第59號1929
4) 大野内記:腺病の發生機轉に就て大阪醤學會雑誌第8巻第9號大正14年
5) 蘆名泰:眼結膜鼻腔咽腔よりの結核菌累積的感染の結果に就て(實驗的研究)結核第6巻第9號昭和3年
6) 加藤謙一:結核菌皮膚侵入感染機轉に關する新實驗(第1報告)結核第5巻第7號昭和2年
8) 光田健輔:癩病の眼疾患に就て日本醫學第65號1910
12) 市川清:眼の癩腫に就て日本眼科學會雑誌第11巻1907
13) 増田隆:癩性點状角膜炎の病理解剖中央眼科醫報第12巻1920
14) 鮫島近二:癩性眼球の組織學的研究日本眼科學會雑誌第36巻1932
17) 瀬木本雄:前鞏膜のレプラ腫に就て日本眼科學雑誌第27巻1923
18) 行徳勝人:眼球癩の臨床的竝に病理組織學的知見補遣日本眼科學會雑誌 1926
19) 内田守:鼠癩の眼疾患に關する研究(第3報) レプラ第4巻第3號昭和8年
20) 籾木穂積:正常ラツテ眼の組織學的研究(第1報告)成醫會雑誌51巻7號昭和7年
22) 有住三郎:癩患者涙液中の抗酸性菌に就いてレプラ第4巻第3號昭和8年
23) 橋本喬:癩及び癩菌の研究に關する2,3の考察大阪醫事新誌7巻7號昭和11年
24) 櫻井方策癩菌の皮膚侵入に關する實驗的研究レプラ第6巻第2號昭和10年
25) 櫻井方策:癩菌の皮膚侵入に關する實驗的研究(第2報) レプラ第7巻第2號昭和11年.

訂正日: 2008/12/10 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

抄録

Leprosy is believed to be one of chronic contagious diseases, which is transmitted by contact. In the previous experiments the author painted an emulsion of a leprous nodule on the skin of the human body and rabbit. With a piece of the painted skin serial sections for microscopic examination were made. In these sections lepra bacilli were found penetrating the skin through a small crack or even an intact continuity. The penetration of the bacilli through the skin also was demonstrated in the skin of the mouse, in which the skin was rubbed after painting the emulsion, or with the rabbit, in which the hair was plucked off. These experimental results were reported in No. 2 of Vol. VI and VII of the journal Lepro.
In this experiment, 5 rabbits were employed and the emulsion was dropped into the conjunctival sac continuously for 30 minutes. In one of these rabbits the lachrymal duct was destroyed by cautery. Then the conjunctiva was excised for a microscopic examination.
In the nrst rabbit (No. 9) 3 bacilli could be found after examining 347 sections, in the second (No. 10) 11 bacilli in 155 sections, in the third (No. 11) 7 bacilli in 382 sectioi and in the forth with a closed lachrymal duct 5 bacilli in 103 sections. Among the penetrating bacilli 19 existed in the deep layer of the cutis, 7 in the middle layer, 4 close by the epithelial layer and 4 direct beneath the epithelium. One bacillus was found in the neibourhood of the Meibom's gland as well as in the wall and in the hollow of blood vessels respectively.
From these findings it was stated that lepra bacilli could enter into the deep layer of the cutis through the epithelial layer of the conjunctiva, and the bacilli in the cutis into the blood vessel penetrating the wall.
The question as to whether or not a leprous change could be caused by the bacilli, which entered into the cutis of the conjunctiva, was not solved. But summarizing the experimental works carried out by the present author, the skin could be regarded as a more favourable source than the conjunctiva, since the skin was far larger in extension and had far more occasions to contact with leprous carriers than the latter.

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