各種近交系マウスのMycobacterium aviumに対する感受性

2) 皮下感染例について

抄録

Avian tubercle bacilli, strain Kirchberg, were inoculated subcutaneously on the thorax of 5 inbred strains of mice, C3H, C57BL/6, DDD, BALB/c and KK, in order to examine the development of local and visceral lesions at varying time intervals.
In almost all the mice of each strain, a small, hard and sharply defined nodular infiltrate developed at the inoculation site within 2 to 3 weeks. At about 10 to 15 weeks, the nodule stopped growing and tended to regress spontaneously. And in all the mice examined the visceral lesions were slight at that time.
At the late stage of infection, however, there were remarkable differences in their visceral lesions among the tested strains of mice, while subcutaneous lesions were still slight. At 35 to 50 weeks, extensive involvement was found in the lung, liver and spleen of KK and BALB/c mice. And many bacilli-loaded cells were found in the lung of C57BL/6 mice. On the contrary, visceral lesions of C3H and DDD mice were very slight even in the late stage of infection.
Mouse strain differences in visceral lesions of the subcutaneously infected mice showed similar tendencies to those of the intraperitoneally infected mice.