Self-organized Lattice Control of Hydroxyapatite and Adsorption Property of Bioactive Substance

Abstract

We prepared nano-crystalline Zn-containing hydroxyapatite (ZnHAp) by the wet-chemical method and examined the selective adsorption of essential proteins, taking bovine serum albumin (BSA) and pathogenic protein such as β₂-microglobulin ( β₂-MG) as model proteins. Transmission electron microscopy observation and X-Ray diffraction analysis indicated that the increase of Zn content led to smaller crystallites and their specific surface area of ZnHAps increased with increasing the Zn content. Furthermore, the amounts of BSA adsorption on ZnHAp particles decreased with increasing the Zn content in spite of the increase in the specific surface area. It is thus concluded that nano-crystalline ZnHAps had a high selective adsorption property in regard to β₂-MG.