Human Stem Cell Culture Supernatant, a product of regenerative medicine and stem cell research, contains various cell growth factors and bioactive substances. It has diverse and multifaceted mechanisms of action, so that it is capable of activating cellular functions and promoting the production of constituent components. Consequently, it has attracted attention as a groundbreaking cosmetic ingredient and is being used accordingly.
In this paper, the functionality of a smart technology that fuses human stem cell culture fluid and PLGA nanospheres was verified. The results suggest excellent collagen-producing ability, especially in the epidermis and dermis, and indicate that the technology can be expected to be utilized in aging care cosmetics. It has been demonstrated that PLGA NS work as a highly useful delivery technology, which facilitates penetration of ingredients like HSCCS, despite their large molecular size, deep into the skin, and retains them at the site of action, ensuring a long-lasting effect.
Recently, the fusion of regenerative medicine and nanotechnology has been garneringgarnered attention in the field of cosmetics. The combination of Human Stem Cell Culture Supernatant and PLGA nanotechnology, pursued by the authors, offers an innovative approach to skin regeneration and rejuvenation, and is also being applied in the development of cosmetics. This paper focuses on the cosmetic effects of this combined technology and its potential for future medical applications.
The “Nano DDS-type hair-growth agent with PLGA nanospheres” is our core technology and has a high hair-growth effect, and has been actually used for hair growth in humans. In this report, we present the results of an in vitro test using dermal papilla cells, which play a central role in the normalization of the hair cycle, which is essential for hair growth, and in the formation and growth of hair follicles. In experiments using cells, we evaluated cell activating effects, gene expression of hair growth-promoting factors, and expression-suppressing effects of genes related to hair loss. The results showed that PLGA NS, which contains hair-growth components, has effects on the activation of papilla cells, normalization of the hair cycle, promotion of hair follicle formation, promotion of blood flow, and prevention of telogen effluvium transition (hair loss). These effects indicate that PLGA NS is an extremely useful delivery technology that allows hair-growth ingredients to penetrate deep into the pores and remain at the site of action for a sustained effect.
At the Hosokawa Micron Pharmaceutical and Beauty Science
Research Center, extensive efforts have been dedicated to developing a hair
growth agent that utilizes PLGA nanospheres for targeted delivery deep into the
pores (intracellular). This paper validates, through assessments involving hair
papilla cells, the enhancement of cellular functionality by the
intracellular introduction of PLGA nanospheres, demonstrating the promotion of hair cycle gene expression and suppression of hair loss gene
expression. These findings represent intriguing outcomes in the pursuit of
enhancing the efficacy of hair growth ingredients.
DRYMEISTER® (model: DMR), which continues to evolve through numerous improvements and modifications since its development in 2000, is a representative model with high efficiency as a dryer. This dryer has a high-speed dispersion/pulverization mechanism and is also equipped with a classification mechanism. Experimental results and considerations are reported are reported, focusing on the improvement of drying efficiency, compactness, easy access cleaning, and reduction of adhesion, which are required for high-speed airflow direct heating dryers.
DRYMEISTER® (DMR), a direct heating type dryer using high-speed airflow, is a multifunctional powder processing equipment that can simultaneously dry, grind, and classify wet powder materials. Various improvements have been made since it was developed in 2000, but this time, while the basic concept remains the same, the main body of the machine has been significantly shortened and made more compact, reducing the amount of material that adheres inside the machine. Experimental results have shown that the dryer has a higher grinding performance than conventional machines, and is expected to be used as a new useful dryer.
There are various types of particle measurement methods, and particle size measurement by image analysis is effective for evaluating the shape of particles and evaluating coarse particles contained in very small amounts. The Parshe Analyzer®, which is a dynamic particle image analyzer, and the optional Auto Sampler, which is an automatic sample preparation and dispensing device, are introduced with examples of actual powder measurement.
Evaluation of powder particle shape and detection of small amounts of coarse particles are important for various powder materials, such as electrophotographic developer materials, and we use dynamic image analysis methods that can measure and evaluate them in a short time. Actual measurement results have shown that the Parshe Analyzer is a measurement device with excellent detection sensitivity and operability because of its automatic focus adjustment and automatic lens magnification switching. In addition, more stable measurement results have been obtained using an automatic pretreatment device, Auto Sampler (PAS-AS) equipped with a stirrer and an ultrasonic dispersion mechanism.
Sustainability is an important and indispensable keyword for the survival and development of companies in a near-future society facing the problem of global warming. Reducing greenhouse gas (GHG) emissions and tackling climate change issues, which previously had only been an issue for large corporations, now require the entire world to work together. As a company listed on the First Section of the Tokyo Stock Exchange, we bear the responsibility to contribute to these global endeavors. To fulfill our role as a member of a sustainable society and become a company that prioritizes sustainability, we must address these issues through our business activities and implement measures to achieve the Sustainable Development Goals (SDGs). To address sustainability as a company-wide activity, we have formed project teams with the help of external consultants. The first team developed a GHG emissions estimation model and conducted an emissions estimation study based on this model. Additionally, they proposed a materiality plan, which also serves as an action guideline for reducing GHG emissions. The second team analyzed climate change scenarios and proposed disclosures on the Task Force on Climate-related Financial Disclosures (TCFD) in accordance with the Corporate Governance Code. Both initiatives have received management approval and are now available on our website.
In a near future society facing the problem of global warming, sustainability has become a very important keyword for the survival and development of companies. As a company-wide initiative, the Hosokawa Micron Group has formed project teams with the cooperation of external consultants to advance efforts toward achieving the Sustainable Development Goals (SDGs). These allowed us to estimate greenhouse gas (GHG) emissions, develop a materiality plan to reduce them, and disclose proposals to the Task Force on Climate-related Disclosure (TCFD) in line with the Corporate Governance Code.
Electrode Structure and Performance of Li-ion Batteries
Released on J-STAGE: October 03, 2018 | Volume 53 Pages 21-24
Yoshio UKYO
New Powder Processing for the Development and Improvement of Manufacturing Technologies of Battery Materials―Particle Design Technology for the Advanced Functioning of Lithium Ion Rechargeable Battery―
Released on J-STAGE: October 03, 2018 | Volume 55 Pages 38-47
Toyokazu YOKOYAMA, Yoshiyuki INOUE
Carbon-Material Design for Conductive Material in Rechargeable Batteries
Released on J-STAGE: October 03, 2018 | Volume 55 Pages 58-62
Tetsuya WADA
Potential and Possibility in Mechanochemical Method and Process ~Up-grading and functionalization of materials and resources~
Released on J-STAGE: October 03, 2018 | Volume 51 Pages 24-29
Fumio SAITO
Development of High-performance Li-ion Battery and Relation to the Powder Process Engineering
Released on J-STAGE: October 03, 2018 | Volume 54 Pages 12-18
Shin FUJITANI