Human Stem Cell Culture Supernatant, a product of regenerative medicine and stem cell research, contains various cell growth factors and bioactive substances. It has diverse and multifaceted mechanisms of action, so that it is capable of activating cellular functions and promoting the production of constituent components. Consequently, it has attracted attention as a groundbreaking cosmetic ingredient and is being used accordingly.

In this paper, the functionality of a smart technology that fuses human stem cell culture fluid and PLGA nanospheres was verified. The results suggest excellent collagen-producing ability, especially in the epidermis and dermis, and indicate that the technology can be expected to be utilized in aging care cosmetics. It has been demonstrated that PLGA NS work as a highly useful delivery technology, which facilitates penetration of ingredients like HSCCS, despite their large molecular size, deep into the skin, and retains them at the site of action, ensuring a long-lasting effect.

The “Nano DDS-type hair-growth agent with PLGA nanospheres” is our core technology and has a high hair-growth effect, and has been actually used for hair growth in humans. In this report, we present the results of an in vitro test using dermal papilla cells, which play a central role in the normalization of the hair cycle, which is essential for hair growth, and in the formation and growth of hair follicles. In experiments using cells, we evaluated cell activating effects, gene expression of hair growth-promoting factors, and expression-suppressing effects of genes related to hair loss. The results showed that PLGA NS, which contains hair-growth components, has effects on the activation of papilla cells, normalization of the hair cycle, promotion of hair follicle formation, promotion of blood flow, and prevention of telogen effluvium transition (hair loss). These effects indicate that PLGA NS is an extremely useful delivery technology that allows hair-growth ingredients to penetrate deep into the pores and remain at the site of action for a sustained effect.

DRYMEISTER^® (model: DMR), which continues to evolve through numerous improvements and modifications since its development in 2000, is a representative model with high efficiency as a dryer. This dryer has a high-speed dispersion/pulverization mechanism and is also equipped with a classification mechanism. Experimental results and considerations are reported are reported, focusing on the improvement of drying efficiency, compactness, easy access cleaning, and reduction of adhesion, which are required for high-speed airflow direct heating dryers.

There are various types of particle measurement methods, and particle size measurement by image analysis is effective for evaluating the shape of particles and evaluating coarse particles contained in very small amounts. The Parshe Analyzer^®, which is a dynamic particle image analyzer, and the optional Auto Sampler, which is an automatic sample preparation and dispensing device, are introduced with examples of actual powder measurement.

Sustainability is an important and indispensable keyword for the survival and development of companies in a near-future society facing the problem of global warming. Reducing greenhouse gas (GHG) emissions and tackling climate change issues, which previously had only been an issue for large corporations, now require the entire world to work together. As a company listed on the First Section of the Tokyo Stock Exchange, we bear the responsibility to contribute to these global endeavors. To fulfill our role as a member of a sustainable society and become a company that prioritizes sustainability, we must address these issues through our business activities and implement measures to achieve the Sustainable Development Goals (SDGs). To address sustainability as a company-wide activity, we have formed project teams with the help of external consultants. The first team developed a GHG emissions estimation model and conducted an emissions estimation study based on this model. Additionally, they proposed a materiality plan, which also serves as an action guideline for reducing GHG emissions. The second team analyzed climate change scenarios and proposed disclosures on the Task Force on Climate-related Financial Disclosures (TCFD) in accordance with the Corporate Governance Code. Both initiatives have received management approval and are now available on our website.