Hosokawa Powder Technology Foundation ANNUAL REPORT
Online ISSN : 2189-4663
ISSN-L : 2189-4663
Research Grant Report
Preparation of Polymeric Microspheres Coated With Bone-Like Nanoapatite
Masakazu Kawashita
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2007 Volume 15 Pages 22-29


Bioactive polymeric microspheres can be produced by coating with a calcium silicate solution and the subsequent soaking in a simulated body fluid (SBF). Such combination should allow for the development of bioactive microspheres for several applications in the medical field including tissue engineering. Four types of polymeric microspheres with different sizes were used: (i) ethylenevinyl alcohol co-polymer (20-30μm), (ii) polyamide 12 with 10% of hematite (100mm), (iii) polyamide 12 (10-30μm) and (iv) polyamide 12 (300μm). These microspheres were soaked in a calcium silicate solution at 36.5oC for different periods of time under several conditions. Afterwards, they were dried in air at 60 and 100oC for 24 hrs. Then, the samples were soaked in SBF for 1, 3 and 7 days. Fourier transformed infrared spectroscopy, thin-film X-ray diffraction, and scanning electron microscopy showed that after the calcium silicate treatment and the subsequent soaking in SBF, the microspheres successfully formed a apatite layer on their surfaces in SBF within 7 days due to the formation of silanol (Si-OH) groups effective for apatite formation.

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