Mechano-Processing of Hollow and/or Composite Bio-Materials

Abstract

Core/shell microspheres (core : polymethylmethacrylate (PMMA, ca. 90 μm in diameter), shell : hydroxyapatite (HA) mixed with a small amount of fumed silica) could be prepared by employing a mechanofusion system. The shell thickness and surface roughness of hollow microspheres, which were obtained by heat-treatment (1200℃ in air) of the core/shell microspheres, could be controlled by adjusting the mixing ratio of HA-based powders and PMMA microspheres in the raw materials. A mixture of the core/shell composites and a HA sol was subjected to firing at 1200℃ in air to prepare porous HA bodies. The amount of protein adsorbed increased with an increase in pore volume of the porous HA bodies.