Hosokawa Powder Technology Foundation ANNUAL REPORT
Online ISSN : 2189-4663
ISSN-L : 2189-4663
Research Grant Report
Formation of Lipid Nanoparticles and Elucidation of Formation Mechanism
Manabu TOKESHI
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RESEARCH REPORT / TECHNICAL REPORT FREE ACCESS

2016 Volume 24 Pages 74-78

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Abstract

In order to elucidate the formation mechanism of lipid nanoparticles in microfluidic devices, we investigated the formation behavior of lipid nanoparticles in microfluidic devices with a staggered herringbone micromixer structure. The microfluidic devices were fabricated with varying the staggered herringbone micromixer cycle numbers to confirm the effect of mixing the solutions on the LNP formation. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) was dissolved in ethanol to obtain a concentration of 10 mg/mL lipid solution. 154 mM NaCl was used for the aqueous solution. The size of the lipid nanoparticles was analyzed by dynamic light scattering. From the obtained results, we assumed that the rapid decrease of ethanol concentration to its critical concentration was essential to form lipid nanoparticles.

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This article is licensed under a Creative Commons [Attribution 2.1 Japan] license.
https://creativecommons.org/licenses/by/2.1/jp/
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