Research Grant Report
Production of PLGA Nanoparticles and Its Application to Drug Delivery Systems
2020 Volume 28 Pages 88-92
Details
2020 Volume 28 Pages 88-92
In this study, we demonstrated the precise size control of Poly lactic-co-glycolic acid (PLGA) nanoparticles using our microfluidic device named iLiNP®. The size of PLGA nanoparticles was able to control ranged from 30 to 120nm by the flow conditions using the iLiNP device. The iLiNP device was also applied to produce the PEG-PLGA nanoparticles and paclitaxel (PTX)-loaded PLGA nanoparticles. We confirmed the physical properties including average-size, size distribution, and encapsulation efficiency of PTX were enough to evaluate for in vivo and in vitro assays.
