Development of Technology to Improve Powder Properties Based on Coamorphous Formation

Abstract

The purpose of this study was to improve the solubility of three poorly water-soluble polyphenols by amorphous formation with naringin (NAR). All spray-dried particles showed a halo pattern in powder X-ray diffraction measurements and showed a single glass transition temperature in differential scanning calorimetry. The spray-dried particles of poorly-water soluble polyphenols and NAR improved the solubility of hydrophobic polyphenols, especially the solubility of naringenin, which has a similar structure to NAR, was significantly increased.

Graphical Abstract

Dissolution profiles of (a) flavone, (b) quercetin, and (c) naringenin.