Design of Inhalable Combinations Using Cyclodextrin-Metal-Organic Frameworks

Abstract

We focused on cyclodextrin-metal-organic frameworks (CD-MOFs) as a novel carrier for inhalable microparticles. CD-MOFs have garnered attention in pharmaceutical fields owing to their high biodegradability and safety. Particles produced by spray-drying were found to successfully achieve a high loading of levofloxacin (LVFX) compared to the antisolvent crystallization method. Furthermore, a significantly higher delivery rate to the lungs was observed when comparing particles prepared via spray-drying with those prepared using the antisolvent crystallization method. Additionally, aiming for the design of inhalable combination drugs, particles were prepared via spray-drying with 4-aminosalicylic acid and isoniazid. These particles demonstrated the formulation of cocrystals, enabling the simultaneous local delivery of drugs with different properties to the lungs.